Signal Integration by the Two-Component Signal Transduction Response Regulator CpxR
نویسندگان
چکیده
منابع مشابه
Two-component signal transduction.
Most prokaryotic signal-transduction systems and a few eukaryotic pathways use phosphotransfer schemes involving two conserved components, a histidine protein kinase and a response regulator protein. The histidine protein kinase, which is regulated by environmental stimuli, autophosphorylates at a histidine residue, creating a high-energy phosphoryl group that is subsequently transferred to an ...
متن کاملCpx two-component signal transduction in Escherichia coli: excessive CpxR-P levels underlie CpxA* phenotypes.
In Escherichia coli, the CpxA-CpxR two-component signal transduction system and the sigma(E) and sigma(32) response pathways jointly regulate gene expression in adaptation to adverse conditions. These include envelope protein distress, heat shock, oxidative stress, high pH, and entry into stationary phase. Certain mutant versions of the CpxA sensor protein (CpxA* proteins) exhibit an elevated r...
متن کاملTwo-component signal transduction in Enterococcus faecalis.
Enterococci are gram-positive constituents of the normal human microflora, typically colonizing the intestinal tract and skin (34, 47). However, these organisms are capable of causing disease as opportunistic pathogens, mainly in immunocompromised patients (35, 58). The problem of enterococcal infection has been aggravated by the emergence in the past decade of multiple antibiotic resistance, w...
متن کاملEvolution of two-component signal transduction.
Two-component signal transduction (TCST) systems are the principal means for coordinating responses to environmental changes in bacteria as well as some plants, fungi, protozoa, and archaea. These systems typically consist of a receptor histidine kinase, which reacts to an extracellular signal by phosphorylating a cytoplasmic response regulator, causing a change in cellular behavior. Although s...
متن کاملTwo-component signal transduction pathways in Arabidopsis.
The two-component system, consisting of a histidine (His) protein kinase that senses a signal input and a response regulator that mediates the output, is an ancient and evolutionarily conserved signaling mechanism in prokaryotes and eukaryotes. The identification of 54 His protein kinases, His-containing phosphotransfer proteins, response regulators, and related proteins in Arabidopsis suggests...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2008
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.01906-07